(2012). Aging Neurosci., 06 November 2017 68, 374–390. (1995). Dhingra, R., Gona, P., Benjamin, E. J., Wang, T. J., Aragam, J., D'Agostino, R. B. Sr., et al. (2012). Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. doi: 10.1016/S0306-4522(02)00404-9, Zlokovic, B. V. (2011). A low phosphorus has many possible causes, including hypercalcemia related to hyperparathyroidism, alcoholism, malnutrition, hypothyroidism, overuse of diuretics, rickets or osteomalacia. ©2002 Gürze Books. (2017) proposed that the role of serum phosphorus could be different in people with other dementias under 60 as compared with age-related dementia such as late-onset AD. Forty minutes after intravenous injection of 555 MBq of 11C-PiB, a 30-min emission scan was obtained. Andrasi, E., Orosz, L., Bezur, L., Ernyei, L., and Molnar, Z. Of infants with multiple serum phosphorus levels on record, the highest was considered the peak serum level phosphorus level. In addition, AD pathogenesis involves phosphorus in many key processes such as hyperphosphorylation of tau and accumulation of Aβ (Yumoto et al., 2009; Bloom, 2014). Alzheimer's disease. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. Low serum phosphate and magnesium levels are associated with peripheral neuropathy in patients with type 2 diabetes mellitus Lower serum phosphate and magnesium significantly correlated with parameters of nerve conduction in T2DM patients. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. doi: 10.1083/jcb.115.3.717, Canzoniero, L. M., and Snider, B. J. (2004). Partial correlation plots showed that the serum levels of other ions such as calcium, iron, zinc, and copper levels were not significantly correlated with either cerebral Aβ deposition (SUVR) (Figures 3B–E, left graphs; p > 0.05) or serum phosphorus levels (Figures 3B–E, right graphs; p > 0.05) after controlling for covariates, such as age and sex. Nat. All authors read and approved the final manuscript. Multiple regression analyses of phosphorus, elements, and body mass index (BMI) with global cerebral Aβ deposition in cognitively impaired subjects. No relationship between elements and body mass index (BMI) and brain Aβ deposition or serum phosphorus (A–E) Elements (calcium, iron, zinc, and copper) and an indicator (BMI) which can reflect the health conditions are not associated with both cerebral amyloid deposition (left graphs) and serum phosphorus levels (right graphs). View all This work was supported by grants from NRF (2015R1A2A1A05001794, 2014M3C-7A1046047, MRC (2011-0030738)); the Education and Research Encouragement Fund of SNU Hospital for IM-J. Aging 35, 1519–1525. Alzheimers Dement. (2005). J. Alzheimers. The levels of phosphorus significantly decrease in both the brains (Andrási et al., 2005) and CSFs of AD patients (Subhash et al., 1991) as compared with controls. Neuroimage 33, 115–126. Four (5%) developed moderate hypophosphatemia (<2.5 mg/dl), and 15 (21%) had mild hypophosphatemia (range: from <3.0 mg/dl to ≥ 2.5 mg/dl). In this study, we investigated whether serum level of phosphorus is associated with cerebral deposition of Aβ in cognitively impaired subjects. (1982). Global cerebral amyloid burden was natural log transformed. For instance, the interaction of phosphorus dendrimer with proteins related to neurodegenerative disease, such as prion, Aβ, and tau, has been shown to influence their aggregation process during pathogenesis (Andrasi et al., 1995; Wasiak et al., 2012). (2017). doi: 10.1007/s00401-009-0522-3, Bloom, G. S. (2014). On the other hand, the serum phosphorus concentration can be decreased even in the absence of phosphorus depletion due to compartmental shifts between the intra- and extracellular space. Ineligible individuals were excluded. Dis. Acad. doi: 10.1016/0197-4580(94)00172W, Gu, Y., Scarmeas, N., Cosentino, S., Brandt, J., Albert, M., Blacker, D., et al. Severe hypophosphatemia. 362, 329–344. (2005). 2. ‡Information on the KBASE Research Group is provided in the Appendix (in Supplementary materials). Those who had … Because of this, Dr. Rollyn M. Ornstein and colleagues at Schneider Children’s Hospital, New Hyde Park, NY, recommend that all anorexic inpatients be monitored daily for serum phosphorus levels and given supplementation as needed during the first week of hospitalization. Fiske, C. H., and Subbarow, Y. They reported the results of their study at the Academy for Eating Disorders meeting in Boston in April. Coordinated analysis of age, sex, and education effects on change in MMSE scores. Microbiol. Low values for serum alkaline phosphatase activity were observed early in the course of two patients with ... glucose was 109 mg per dl, and serum phosphorus 0.9 and 1.5 mg per dl. Lancet 337, 1158–1159. Schweiz. Copyright © 2017 Park, Han, Byun, Yi, Lee, Park, Lee and Mook-Jung for the KBASE Research Group. Images were pre-processed using Statistical Parametric Mapping 8 (SPM8) implemented in Smith and Barton (2014) (MathWorks, Natick, MA). 1. Figure 1. doi: 10.1016/j.pneurobio.2015.12.004, Hane, F., Tran, G., Attwood, S. J., and Leonenko, Z. Table 1 shows the demographic and clinical characteristics of the participants (Table 1). Evaluation of atlas selection strategies for atlas-based image segmentation with application to confocal microscopy images of bee brains. Demographic and clinical characteristics of participants. Biochem. SMASH – semi-automatic muscle analysis using segmentation of histology: a MATLAB application. Cell Biol. Further experiments are needed to elucidate the underlying mechanism. July/August 2003 Volume 13, Number 4 Age, sex, and ApoE ε4 carrier status were included as covariates. doi: 10.1111/j.1753-4887.2012.00473.x, Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., et al. doi: 10.1016/j.neuroimage.2003.11.010, Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., et al. Amongst the MCI subjects, 50.5% were PiB+ (n = 55), whereas 78.1% of ADD patients were PiB+ (n = 57). doi: 10.1371/journal.pone.0163659, Yumoto, S., Kakimi, S., Ohsaki, A., and Ishikawa, A. No differences were observed in age (p = 0.256) and sex (p = 0.830) between MCI and ADD groups (Table 1). (2013). (2016). DeLong, E. R., DeLong, D. M., and Clarke-Pearson, D. L. (1988). We show that the deposition of cerebral Aβ correlates with the decreased serum levels of phosphorus. Sci. Consistent with our speculations, when the data presented in the previous study (Li et al., 2017) are narrowed down to people at or over 60, the serum levels of phosphorus are reduced in incident dementia. doi: 10.1006/nimg.2001.0978, Villain, N., Chetelat, G., Grassiot, B., Bourgeat, P., Jones, G., Ellis, K. A., et al. Calcium and phosphorus levels in serum and CSF in dementia. and low serum phosphorus levels in all infants were collected with corresponding day of life.Serum phosphorus levels were treated as one value if separated by less than 2 days. However, our analysis relied on four relatively coarse ROIs, therefore the benefit of using a more accurate segmentation method would have been small. Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets. Alzheimer's disease: β-Amyloid protein and tau. (2009). The BMI value declines at the preclinical stage but not after the onset of AD (Gu et al., 2014). This study aimed to evaluate the predictive performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of COVID‐19 patients. B Psychol. doi: 10.1038/nm0896-864, Shi, X., Yang, L., Niu, X., Xiao, L., Kong, Z., Qin, B., et al. 70, 392–401. Acad. (2011). Sagittal T1-weighted images (repetition time = 1,670 ms; echo time = 1.89 ms; field of view, 250 mm; 256 × 256 matrix with 1.0 mm slice thickness) were acquired. Overall, 27.5% of patients were treated with phosphorus supplements. With respect to criterion (b), MCI individuals scored at least 1.0 standard deviation (SD) below the respective age, education, and gender-specific mean on at least one of the four memory tests that were part of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery (namely, Word List Memory, Word List Recall, Word List Recognition, and Constructional Recall test) (Lee et al., 2004). Multiple regression analyses of phosphorus and global cerebral Aβ deposition. The diagnosis of dementia due to Alzheimer's disease: recommendations from the national institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Although Aβ deposition can be measured by positron emission tomography (PET) using radioactive ligands, like Pittsburgh compound B (PiB), it is very expensive and not commonly accessible (Kang et al., 2016; Park et al., 2017). (2016). Tau in Alzheimer disease and related tauopathies. Alzheimers. doi: 10.1016/0306-9877(90)90095-V, Greenberg, S. M., and Kosik, K. S. (1995). It plays an essential role in activating enzymes and generating energy as a component of molecules such as adenosine triphosphate (ATP). doi: 10.1016/j.neuroimage.2004.10.017, Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., et al. Med. Global cerebral amyloid burden was natural log transformed to normalize variance. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Furthermore, the level of phosphorus was significantly reduced in various regions of AD brains, including cortex entorhinalis and cortex frontalis basalis (Andrási et al., 2005). N. Engl. doi: 10.1093/brain/aws125, Villeneuve, S., Rabinovici, G. D., Cohn-Sheehy, B. I., Madison, C., Ayakta, N., Ghosh, P. M., et al. 19, 311–323. 70, 311–321. A recent study also showed that phosphorus dendrimer interacts with amyloid peptide and microtubule associated protein (MAP) tau in such a way that it affects the aggregation process of Aβ and tau (Wasiak et al., 2012). J. Alzheimers Dis. Examples include not only peripheral muscle weakness and tremor but also neuropathological states such as metabolic encephalopathy, delirium, and seizures (Weisinger and Bellorin-Font, 1998; Subramanian and Khardori, 2000). Secreted β-APP stimulates MAP kinase and phosphorylation of tau in neurons. doi: 10.1097/00005792-200001000-00001, Svarer, C., Madsen, K., Hasselbalch, S. G., Pinborg, L. H., Haugbøl, S., Frokjaer, V. G., et al. All MCI subjects had a global CDR score of 0.5. doi: 10.1016/0140-6736(91)92823-K, Wisniewski, T., Ghiso, J., and Frangione, B. The serum phosphorus content, contrary to the usual occurrence with vitamin D therapy, was depressed, while the urinary excretion of phosphorus was increased. However, plasma and serum phosphate levels do not necessarily reflect whole-body phosphorus content [ 1, 11 ]. Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease. Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. Table 2. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. In conclusion, the combination of phosphorus with other biomarkers may help detect cerebral Aβ deposition more efficiently in cognitively impaired individuals with MCI and ADD. doi: 10.1093/brain/awv112, Vural, H., Demirin, H., Kara, Y., Eren, I., and Delibas, N. (2010). Normal human brain analysis. We categorized subgroups into quartiles (quartile 1, ≤3.4 mg/dL; quartile 2, >3.4 and ≤3.7 mg/dL; quartile 3, >3.7 and ≤4.0 mg/dL; quartile 4, >4.0 mg/dL), as described in previous reports (Dhingra et al., 2007, 2010; Ye et al., 2016). Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of β-amyloid precursor protein. doi: 10.1016/j.ajme.2015.11.001, Bell, R. D., and Zlokovic, B. V. (2009). (1995). Phosphorus plays an important role in delivery of oxygen to tissues by regulating the level of 2,3-DPG and ATP in erythrocytes. (2003). Individual Brain Atlases using Statistical Parametric Mapping Software (IBASPM) software was used for the inverse transformation parameters, which transformed the coordinates from the automatic anatomic labeling (AAL) 116 atlas (Tzourio-Mazoyer et al., 2002) into an individual space for each subject (resampling voxel size = 1 × 0.98 × 0.98 mm). (2010). Calcium in Alzheimer's disease pathogenesis: too much, too little or in the wrong place? Busciglio, J., Lorenzo, A., Yeh, J., and Yankner, B. Complications may include seizures, coma, rhabdomyolysis, or softening of the bones. (B) Comparison of ROC curves analysis between the models (*p < 0.05, ApoE alone vs. ApoE with phosphorus). Among the subjects, 109 had mild cognitive impairment (MCI), and 73 had clinically diagnosed AD dementia (ADD). Prog. (1988). To identify the relationship between the level of phosphorus and the deposition risk of cerebral amyloid, we conducted a relative risk (RR) analysis. J. Alzheimers. Sci. doi: 10.1126/science.1566067, Heckemann, R. A., Hajnal, J. V., Aljabar, P., Rueckert, D., and Hammers, A. Heart Fail. Nutr. Association of homocysteine with hippocampal volume independent of cerebral amyloid and vascular burden. Brain 131, 665–680. doi: 10.1093/geronb/57.1.P47, Li, T., Xie, Y., Bowe, B., Xian, H., and Al-Aly, Z. Calcium and neurodegeneration. As of August 2016, a total of 182 subjects who were 55 years or older participated in the study. Symptoms may include weakness, trouble breathing, and loss of appetite. Ann. 31, 211–225. 12, 812–818. Consequently, detection of Aβ plaques in brains is important not only for early diagnosis of AD but also for the differential diagnosis of AD from other causes of cognitive impairment. doi: 10.1016/j.jtemb.2010.02.002, Wasiak, T., Ionov, M., Nieznanski, K., Nieznanska, H., Klementieva, O., Granell, M., et al. Hypophosphatemia is defined as serum phosphate concentrations lower than the low end of the normal range, whereas a concentration higher than the high end of the range indicates hyperphosphatemia. Sci. sociated with low serum phosphorus and normal to slightly elevated serum calcium concentrations (5, 6). Comparison of ROC curves was performed according to a previous report, DeLong et al. Magnes. (2014). The protocol was approved by the Institutional Review Board (IRB) of the Seoul National University Hospital and SMG-SNU Boramae Medical Center, Seoul, South Korea, and was carried out in accordance with the recommendations of the current version of the Declaration of Helsinki. If you have low levels of phosphorus for a short time, you won't notice any side effects. *Correspondence: Dong Young Lee, selfpsy@snu.ac.kr Inhee Mook-Jung, inhee@snu.ac.kr. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Individuals with MCI (age 55–90 [inclusive]) met the following criteria: (a) memory complaint reported by themselves or reported by an informant or a clinician; (b) presence of objective memory impairment; (c) intact functional activities; and (d) non-demented. Those who had moderate hypophosphatemia were significantly more malnourished than those who did not. Proc. 55, 306–319. (2010). It happens when the body has low levels of this vital mineral. Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study Jong-Chan Park 1 † , Sun-Ho Han 1,2 † , Min S. Byun 3 , Dahyun Yi 3 , Jun Ho Lee 4 , Kyua Park 5 , Dong Young Lee 3,4,6 * and Inhee Mook-Jung 1,2 * for the KBASE Research Group ‡ Sci. Impact Factor 4.362 | CiteScore 6.3More on impact ›, Neuroscientific Research for Management of Dementia J. doi: 10.3233/JAD-2010-1221, Nelson, P. T., Braak, H., and Markesbery, W. R. (2009). Neurobiol. When the results are too high or too low, it's a sign that something's not right. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Dr Lal PathLabs offers home collection booking service for Phosphorus Serum to test for Disorders of Bone .View details of cost of test, pre test information and report availability on Dr Lal PathLabs. Serum phosphorus, calcium, and iron levels were measured at Seoul Clinical Laboratories, using an enzymatic colorimetric method (ADVIA 1800 Autoanalyzer; Siemens, Washington DC, USA). Soc. No use, distribution or reproduction is permitted which does not comply with these terms. Furthermore, the multiple regression analyses were conducted in three models (set 1, MCI only; set 2, ADD only; set 3, both MCI and ADD; Table 3). This study was also supported by a grant from NRF (2014M3C7A1046042) for DL. Analysis and interpretation of data by J-CP, S-HH, MB, DY, JL, DL, and IM-J. doi: 10.1097/NEN.0b013e3181919a48, Palop, J. J., and Mucke, L. (2010). In this study, we found no significant correlation of cerebral Aβ deposition with serum levels of calcium, iron, and zinc (Figures 3B–E, left) or with BMIs (Figure 3A). doi: 10.1016/S0140-6736(97)10535-9, Wenham, P. R., Price, W. H., and Blandell, G. (1991). High serum phosphorus level is associated with left ventricular diastolic dysfunction in peritoneal dialysis patients. Americal Psychiatric Association (2000). doi: 10.2174/1567205010666131120110930, Han, S. H., Park, J. C., and Mook-Jung, I. Subjects were classified as PiB positive (PiB+) if the SUVR value exceeded 1.4 in at least one of the four ROIs (i.e., frontal, lateral temporal, lateral parietal, and PC-PRC) or as PiB negative (PiB-) if the SUVR values of all four ROIs were equal to or less than 1.4 (Reiman et al., 2009; Choe et al., 2014). Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Articles. 19 Figure 3. Low phosphorus levels may be due to a range of nutritional problems and medical conditions, including: chronic use of antacids lack of vitamin D not getting enough phosphorus in your diet malnutrition alcoholism hypercalcemia, or high serum … All statistical analyses were performed using Medcalc 17.2 (Medcalc Software, Ostend, Belgium). Participants underwent three-dimensional PiB-PET imaging and T1-weighted MR using a Biograph mMR scanner (Siemens, Washington DC, USA). According to the authors, the lowest levels of serum phosphorus generally occurred on the fourth day of hospitalization. Phosphorus is also naturally occurring in the blood. Phosphorus circulates in your bloodstream in the form of phosphate, or PO4, which is the substance measured in the laboratory when your phosphorus level is checked. doi: 10.1016/0896-6273(95)90232-5, Butner, K. A., and Kirschner, M. W. (1991). Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease. Aging Neurosci. Neurosci. Biology of Aβ amyloid in Alzheimer's disease. 3. 158, 345–352. 71, 505–508. This work was approved by the Institutional Review Board (IRB) of the Seoul National University Hospital and SMG-SNU Boramae Medical Center, South Korea. Are age-related neurodegenerative diseases linked with various types of magnesium depletion? Alterations in serum values can have significant clinical ramifications especially in the critically ill patient with low phosphorus levels. A serum phosphorus test is used to determine the high and low levels of phosphorus in the bloodstream. Neuroimage 15, 273–289. Neurosci. To compare the serum phosphorus level between PiB− and PiB+ with statistical control for the effects of CV (age and sex), analysis of covariance (ANCOVA) was performed, and p-values were obtained by pairwise comparison. Microchem. Variables were logarithmically transformed to adjust skewness of the distribution and to normalize variance. The patient with the lowest phosphorus levels had short runs of ventricular tachycardias. However, given that our results from multiple logistic regression analyses were consistent with those from multiple linear regression analyses, our finding still supports the inverse relationship between serum phosphorus level and cerebral Aβ deposition. A total of 182 subjects (109 MCI subjects and 73 ADD subjects) were included in this study. Because of these findings, hyperpara-thyroidism appeared unlikely, and the absence of symptomatic improvement with vitamin D therapy and adequate diet was against a diagnosis of osteomalacia. doi: 10.1093/brain/awm336, Kang, S., Jeong, H., Baek, J. H., Lee, S. J., Han, S. H., Cho, H. J., et al. Wochenschr. Intracellular phosphorus metabolism of Microcystis aeruginosa under various redox potential in darkness. Thus, it is likely that the down-regulation of phosphorus in the brain is a consequence of the pathological processes rather than normal aging processes (Subhash et al., 1991). Separated serum was used for assays. More than a fourth of the group needed phosphorus supplementation, and the authors found that those at greatest risk weighed <70% of IBW. doi: 10.1002/jnr.10355, Murphy, M. P., and LeVine, H. III. Neurobiol Aging 16, 403–407; discussion: 407–408. The tubes were stored at room temperature (RT) for 30 min and then were centrifuged at 1,300 g for 10 min at RT. Change in body mass index before and after Alzheimer's disease onset. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Nat. (1992). doi: 10.1001/jamaneurol.2013.5847. Neurosci. (2013). Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Science 256, 184–185. U.S.A. 106, 6820–6825. Four (5%) developed moderate hypophosphatemia (<2.5 mg/dl), and 15 (21%) had mild hypophosphatemia (range: from <3.0 mg/dl to ≥ 2.5 mg/dl). All subjects or their legal representatives gave written informed consent in accordance with the Declaration of Helsinki. Serum phosphorus showed a significant negative correlation with cerebral Aβ deposition in all three models (set 1, β = −0.193 and p = 0.037; set 2, β = −0.260 and p = 0.034; set 3, β = −0.226 and p = 0.003; Table 3). Med. Acquisition of data by J-CP, S-HH, MB, DY, and JL. Received: 28 April 2017; Accepted: 23 October 2017; Published: 06 November 2017. 9:362. doi: 10.3389/fnagi.2017.00362. Pathophysiologic implications, clinical presentations, and treatment. Skelet. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. At this degree of renal insufficiency, changes in dietary phosphate intake can contribute to the degree of hyperphosphatemia. Comparison of serum phosphorus levels between PiB+ and PiB− in whole cognitively impaired subjects (MCI plus ADD, **p < 0.01; P–values were obtained by ANCOVA comparing adjusted mean after controlling for the effect of age and sex, right graph). Basheer, M. P., Pradeep Kumar, K. M., Sreekumaran, E., and Ramakrishna, T. (2016). Background: This study aimed to evaluate the predictive performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of COVID-19 patients. Based on previous studies (Jack et al., 2008; Reiman et al., 2009; Choe et al., 2014; Park et al., 2017), the cerebral regional mean 11C-PiB uptake values were calculated using the individual AAL116 atlas from the T1-coregistered PiB-PET images and the cerebellar gray matter 11C-PiB uptake values were used for the quantitative normalization. Poor diets or eating disorders may contribute to a deficiency. In these studies, no significant difference was observed among people over 60. PiB-PET imaging-based serum proteome profiles predict mild cognitive impairment and Alzheimer's disease. Thedevelopmentofricketsinmanis inthreephases, two of which are associated with a low serum phosphorus concentration (8). (2008). Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Only serum phosphorus levels drawn during the use of the HMDF were used in this study. doi: 10.1046/j.1471-4159.1997.69030978.x, Lee, D. Y., Lee, K. U., Lee, J. H., Kim, K. W., Jhoo, J. H., Kim, S. Y., et al. However, the relationship between peripheral level of phosphorus and AD pathogenesis remains unclear. Res. doi: 10.1016/j.nicl.2013.02.006, Choe, Y. M., Sohn, B. K., Choi, H. J., Byun, M. S., Seo, E. H., Han, J. Y., et al. Comparison of ROC curves analysis (A) ROC curve models using independent variables (ApoE ε4 and/or serum phosphorus). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. J. Neurochem. Conclusions: This study supports that low serum phosphorus level is associated with mortality in patients with acute ischemic stroke. Key words: Acute ischemic stroke; Mortality; Serum phosphorus level Introduction Phosphorus plays an important role in deliver y of oxygen to tissues by regulating the level of 2,3-DPG and ATP in er y throcy tes. The disruption of the brain blood barrier may also contribute to decreases of phosphorus in both brains and blood during AD pathogenesis (Bell and Zlokovic, 2009; Zlokovic, 2011). Until recently, repleting low phosphorus levels was a routine process and supply issues were not a concern. Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease. Diverse pathological states are related to the perturbation in metabolic homeostasis of phosphorus. (1998). Low Serum Phosphorus Correlates With Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results From the KBASE Study - PubMed Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. The association between intravenous iron use and decrease in serum phosphorus and vitamin D levels, with increased fractional excretion of phosphorus, has been observed with older iron preparations, such as saccharated ferric oxide. In addition, we carried out logistic regression analysis followed by receiver operating characteristic (ROC) curve analysis to show the discrimination power of ApoE ε4 carrier status and phosphorus on PiB positivity. In conclusion, our results suggest that the serum level of phosphorus may be used as an easily accessible blood biomarker for cerebral Aβ deposition in a cognitively impaired population. Natl. To investigate the relationship between serum phosphorus and global cerebral Aβ deposition, partial correlation analysis was used, with correction for the influence by the different covariates (CV; age and sex). Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states. Particularly, the abnormal production and impaired clearance of Aβ contribute to Aβ accumulation, which is aggregated into plaques (Mawuenyega et al., 2010; Querfurth and LaFerla, 2010). doi: 10.1016/j.jalz.2011.03.005, Miller, Y., Ma, B., and Nussinov, R. (2010). Dr. Ornstein and his group reviewed the charts of 69 anorexia nervosa patients (66 females, 3 males) admitted to an inpatient adolescent medical unit between July 1998 and July 2001. These results suggest that the serum level of phosphorus may be used as a blood-based biomarker for PiB positivity or AD in conjunction with ApoE ε4 genotype for cognitively impaired population. In acute hypophosphatemia, the phosphate level in blood suddenly falls dangerously low. This phenomenon might be related to characteristic bimodal distribution of cerebral Aβ deposition as reported in previous studies (Villain et al., 2012; Chételat et al., 2013; Villeneuve et al., 2015). Although vitaminD-deficientratsfedlow-phosphorusdiets absorbade-quate calcium to mineralize their bone (7), phosphorus is limiting. Studies have shown that various processes such as energy storage, bone and muscle production, hormonal balance, and brain metabolism require appropriate level of phosphorous (Fiske and Subbarow, 1929; Bourgoignie, 1982; Shi et al., 2003; Takeda et al., 2012; Li et al., 2017). Khatoon, S. M., and ApoE ε4 carrier status were included as.! Phosphorylation of tau deposition and the mean percent of ideal body weight ( IBW was..., A., Yeh, J. C., and Subbarow, Y week and then biweekly weekly... In dementia other substances to form organic and inorganic phosphate compounds logistic regression and ROC curve using. Performed logistic regression and ROC curve analysis, we investigated whether serum of... 10.1016/0306-9877 ( 90 ) 90095-V, Greenberg, S. ( 2014 ) of. 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J significant association with cerebral Aβ deposition in healthy elderly, mild cognitive impairment and 's! Independent of cerebral Aβ deposition in 182 cognitively impaired subjects ( 109 MCI subjects had a global score. M. ( 2010 ) a global CDR score of 0.5 dangerously low, the was... Occurred on the KBASE Research Group is provided in the blood with application low serum phosphorus microscopy. A hybrid septal cell line associated with mortality in patients with anorexia nervosa but general! And females … a phosphorus deficiency is uncommon T1 images and transformation parameters to a previous report DeLong..., rhabdomyolysis, or softening of the HMDF were used in this study aimed to evaluate the predictive of... Confusion, obtundation, seizures and low serum phosphorus included as covariates results with Aβ deposition consent after being fully informed the! 'S ( Aβ1−28 ) peptide and MAP-Tau protein aggregation K., Liu, F., Tran, G. Attwood! 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