Although the mechanism is not well understood, antiemetics are useful in the treatment of nausea, and of the headache itself. Promethazine: Antidopaminergic effect due to blocking mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain; antihistaminic effect due to blocking H1-receptors. Promethazine: 9.1 Mechanism of action/Effect: Antihistaminic (H 1-receptor)—Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. The mode of action of promethazine in potentiating narcotic drugs WebMD provides common contraindications for Promethazine Oral. Mechanism of Action. The symptoms of allergies include runny nose, sneezing, streaming eyes and itching due to a skin reaction. Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). Thus the problem associated with promethazine hydrochloride will be overcome by formulating it into transdermal film. Learn term:antiemetic = promethazine (phenergan) with free interactive flashcards. Mechanism of Action/Drug Effect: Indication: Side effect (expect this): Adverse Effect (bad reaction): Interaction & Contraindication (DO NOT GIVE if): Nursing responsibility (Before, During & After Administration): Assessment/Additional notes: Reference: Fill out all this information for the drug promethazine It has antagonistic effects on muscarinic and NMDA receptors which contribute to its use as a sleep aid and for controlling anxiety and tension. Find out what health conditions may be a health risk when taken with Promethazine Oral It may help with some symptoms associated with the common cold. Promethazine may be used to treat symptoms of allergies. Although promethazine is classified as a phenothiazine, its ability to antagonize dopamine is approximately one-tenth that of chlorpromazine. Promethazine Review. Ondansetron is a serotonin-3 (5-hydroxytryptamine-3, 5-HT 3) receptor antagonist, have been shown to have a good antiemetic effect in patients receiving chemotherapy and in situations with vomiting after surgery 1). Mechanism : Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. However, the mechanism of action of promethazine has not been elucidated. Codeine: Narcotic agonist analgesic with antitussive activity, mu receptor agonist. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as motion sickness, or before/after surgery).It is also used to treat allergy symptoms such as rash, itching, and runny nose.It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. It does not affect the release of Histamine. Promethazine is contraindicated in pediatric patients < 2 years because of potentially life-threatening respiratory depression. Promethazine oral tablet is a prescription drug used to treat several conditions. Used in the treatment of wet cough. Be aware that antiemetic action may mask symptoms of unrecognized disease and signs of drug overdosage as well as dizziness, vertigo, or tinnitus associated with toxic doses of aspirin or other ototoxic drugs. The oral absorption of promethazine is rapid and complete. ATC Classification . Other phenothiazines derivatives include prochlorperazine and chlorpromazine. Antiemetics are a heterogeneous group of drugs used to treat various causes of nausea and vomiting.Different antiemetics act on different receptors, and they may have a … They thereby prevent, but do not reverse, responses mediated by histamine alone. Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm. Promethazine is a first-generation antihistamine. Choose from 54 different sets of term:antiemetic = promethazine (phenergan) flashcards on Quizlet. Promethazine also acts as an antihistamine. Mechanism of Action of Promethazine Antiallergic actions: Promethazine mainly acts on H1 receptor. Promethazine is an antagonist for histamine H1 receptors, which made it useful for treatment of allergies. Its duration of action is usually 4-6 hours (but can be up to 12 hours). What are the Actions of Promethazine (Promethacon) Nursing Pharmacology Considerations? It may also be used for sedating people who are agitated or anxious. Promethazine is in a class of medications called phenothiazines. Promethazine may potentiate the sedative action of other CNS depressants such as barbiturates, antihistamines, tranquillisers, opioids, general anaesthetics, or alcohol. Its anticholinergic properties can cause side effects like dry mouth, constipation, urine retention, and hyperglycemia. 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